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Diurnal rhythm of serum osteocalcin in normal children
Author(s) -
Heuck C,
Skjærbæk C,
Wolthers OD
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01760.x
Subject(s) - osteocalcin , circadian rhythm , medicine , endocrinology , diurnal temperature variation , alkaline phosphatase , biology , enzyme , biochemistry , atmospheric sciences , geology
The aim of the present study was to assess diurnal levels of serum osteocalcin in normal children using a recently introduced fluoroimmunoassay (Pharmacia Osteocalcin CAP FEIA) measuring solely the intact peptide. Five girls and two boys aged 10.4–13.6 (mean 12.2) y were studied. Blood samples for determination of osteocalcin were collected every 2h throughout the day. A statistically significant rise in serum osteocalcin ( F = 6:7, p < 0:001) with a peak at 08.00 h and a nadir lasting from 10.00 to 24.00 h was found. Trough and peak levels (at 16.00 and 08.00 h, respectively) were 41.6 ± 6.8 and 66.0 ± 10.5 /μg l ‐1 (mean ± SEM). The circadian variation should be taken into consideration when single assessments of serum osteocalcin in children are performed.