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Fatty acid composition in colostrum and mature milk from non‐atopic and atopic mothers during the first 6 months of lactation
Author(s) -
Yu G,
Duchén K,
Björkstén B
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01738.x
Subject(s) - colostrum , docosahexaenoic acid , docosapentaenoic acid , polyunsaturated fatty acid , linoleic acid , eicosapentaenoic acid , medicine , atopic dermatitis , lactation , atopy , fatty acid , alpha linolenic acid , breast milk , composition (language) , arachidonic acid , endocrinology , food science , pregnancy , biology , biochemistry , asthma , immunology , antibody , genetics , linguistics , philosophy , enzyme
The fatty acid composition of total lipids was analysed in colostrum and mature human milk samples obtained at 1, 3, 4 and 6 months from 17 non‐atopic and at 1 and 3 months from 17 atopic mothers. The relative levels of linoleic acid and α‐linolenic acid increased up to 3 months after delivery and then declined. In contrast, the levels of their metabolites were higher in colostrum than in mature milk. The levels of dihomo‐γ‐linolenic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid were all lower in atopic than non‐atopic mothers in milk samples obtained after 1 month of lactation (all p < 0:05). The ratio of total n ‐6 to n ‐3 long‐chain polyunsaturated fatty acids (LCP) in milk at 1 and 3 months was higher in atopic than non‐atopic mothers (all p < 0:05). Lower levels of the monounsaturated fatty acids (MUFA) were also observed in atopic mothers, as compared to non‐atopic mothers. In the non‐atopic mothers, the levels of individual n ‐6 LCP correlated and also correlated with n ‐3 LCP in colostrum and early mature milk ( r = 0:60‐0.92, all p < 0:01). These correlations within n ‐6 and between n ‐6 and n ‐3 LCP were mostly absent in atopic mothers. The findings suggest that the LCP metabolism in human milk is disturbed in atopic mothers, as indicated by the lower relative levels of some LCP at 1 month, higher ratios of n ‐6 to n ‐3 LCP and poor correlations between the levels of the various compounds during the first 3 months of lactation.