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Nephropathy and hypertension as manifestations in a 13‐y‐old girl with primary antiphospholipid syndrome
Author(s) -
Ohtomo Y,
Matsubara T,
Nishizawa K,
Unno A,
Motohashi T,
Yamashiro Y
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01559.x
Subject(s) - medicine , thrombotic microangiopathy , urokinase , warfarin , dipyridamole , nephropathy , aspirin , renal function , thrombosis , antiphospholipid syndrome , surgery , thrombotic thrombocytopenic purpura , microangiopathy , gastroenterology , diabetes mellitus , endocrinology , platelet , disease , atrial fibrillation
Severe renal hypertension due to both unilateral renal arterial occlusion and renal thrombotic microangiopathy developed in a 13‐y‐old girl as a manifestation of primary antiphospholipid antibody syndrome. The combination of the intravenous high‐dose urokinase therapy and oral anticoagulation therapy, comprising aspirin, warfarin and dipyridamole, was significantly effective in improving her renal function and preventing thrombotic events during an 18‐month follow‐up period.