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Bacterial genotype and neurological complications of Escherichia coli O157:H7‐associated haemolytic uraemic syndrome
Author(s) -
Cimolai N,
Carter JE
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01510.x
Subject(s) - genotype , escherichia coli , medicine , haemolytic uraemic syndrome , shiga toxin , enterobacteriaceae , bacteria , complication , toxin , microbiology and biotechnology , shiga like toxin , immunology , biology , gene , genetics
We examined the possibility of an association between the bacterial genotype of Escherichia coli O157:H7 and the likelihood of progression to neurological complications in childhood gastroenteritis‐associated haemolytic uraemic syndrome (D+HUS). Bacterial stool isolates were available from 51 patients with HUS; 11 of these patients suffered a neurological complication. Bacteria were assessed for plasmid content, verotoxin (Shiga‐like toxin) profile, verotoxin 2 subtype, and presence of the eaeA (effacement and attachment) marker. No association of bacterial genotype with central nervous system (CNS) manifestations was observed. Whilst the cause of CNS manifestions may be multifactorial, there is no evidence at present to implicate specific bacterial traits.