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Once versus twice daily injections of growth hormone in children with idiopathic short stature
Author(s) -
Phillip M,
Hershkovitz E,
Belotserkovsky O,
Leiberman E,
Limoni Y,
Zadik Z
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01496.x
Subject(s) - medicine , short stature , idiopathic short stature , bone age , growth hormone , growth hormone deficiency , linear growth , endocrinology , growth velocity , growth hormone treatment , hormone , insulin like growth factor , growth factor , receptor , mathematics
The aim of this study was to compare the growth response of 22 short pre‐pubertal children without growth hormone deficiency, treated with a single daily growth hormone injection (group A), to the growth response of 27 similar children, treated with the same daily dose divided into 2 subcutaneous injections per day (group B), for 1 y, in a randomized study. GH treatment significantly promoted growth parameters, height standard deviation score and height velocity standard deviation score in both groups. Serum insulin‐like growth factor I was also increased. There were no significant differences in growth response, serum IGF‐I levels, or the advance in bone age between the two study groups after 1 y of GH therapy. We conclude that twice daily s.c. growth hormone injections provide no advantages over once daily injection of the same dose in promoting the linear growth of short children without growth hormone deficiency.