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Adhesion inhibitory activity of β‐lactoglobulin isolated from infant formulae
Author(s) -
Ouwehand AC,
Salminen SJ
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01491.x
Subject(s) - adhesion , medicine , in vitro , microbiology and biotechnology , infant formula , escherichia coli , biochemistry , chemistry , biology , organic chemistry , pediatrics , gene
β‐Lactoglobulin was isolated from infant formulae that were ultra high temperature (UHT) ‐treated, sterilized or spray‐dried. The effect of the isolated β‐lactoglobulin on SfaII‐fimbriae‐mediated adhesion of Escherichia coli to human ileostomy glycoproteins was studied in vitro. β‐Lactoglobulin isolated from sterilized formulae was found to perform significantly less well than preparations from spray‐dried formulae (p = 0:05). Great heterogeneity was observed in the adhesion inhibitory capacity of β‐lactoglobulin isolated from UHT‐treated formulae. Therefore, no significant difference was observed between UHT‐treated and sterilized formulae or spray‐dried formulae (p < 0:10). It can be hypothesized that β‐lactoglobulin from spray‐dried and some UHT‐treated infant formulae may affect the colonization of mucous membranes by E. coli strains causing neonatal septicaemia and meningitis.