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Enterovirus‐associated haemophagocytic syndrome in a neonate
Author(s) -
Barre V,
Marret S,
Mendel I,
Lesesve JF,
Fessard Cl
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01482.x
Subject(s) - medicine , hepatosplenomegaly , macrophage activation syndrome , coagulopathy , enterovirus , hemophagocytic lymphohistiocytosis , consumptive coagulopathy , hemophagocytosis , immunology , pediatrics , bone marrow , pancytopenia , virus , disease , arthritis
A 3‐d‐old neonate presented with fever, hepatosplenomegaly, coagulopathy, thrombopenia and anaemia. Secondary haemophagocytic lymphohistiocytosis was suspected, as persistent cytopenias were associated with hypofibrinogenaemia, haemophagocytosis in bone marrow and decreased NK cell. There was no positive family lymphohistiocytosis history or parental consanguinity. Bacterial investigation proved negative. The diagnosis of enterovirus maternofoetal infection was carried out. The infant's condition improved with symptomatic therapy from day 7. Follow up at 1 y was normal without relapse. This is the first report of a neonatal enteroviral infection that was responsible for excessive macrophage activation.