Premium
Relationship of apolipoprotein E phenotypes to serum lipid and lipoprotein levels in Japanese schoolchildren
Author(s) -
Okada T,
Sato Y,
Iwata F,
Hara M,
Kim H,
Harada K
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01480.x
Subject(s) - phenotype , apolipoprotein e , medicine , apolipoprotein b , lipoprotein , endocrinology , cholesterol , total cholesterol , high density lipoprotein , genetics , biology , gene , disease
The distribution of apolipoprotein (apo) E phenotypes was investigated in Japanese schoolchildren and an attempt was made to determine whether the apoE phenotypes influence the serum levels of lipid and lipoprotein. The subjects were 289 children from ajunior high school (145 M, 144 F, aged 12–13 y). TheE 3/3 phenotype was demonstrated in 69.9%, E 4/3 in 18.7%, E 2/3 in 9.0%, E 4/2 in 1.4%, E 4/4 in 0.7% and E 5/4 in 0.3%. E 2/2 was not detected. Serum levels of total cholesterol and low‐density lipoprotein‐cholesterol were progressively lower in the phenotypes E 4/3 , E 3/3 and E 2/3 . The serum level of high‐density lipoprotein‐cholesterol showed a progressive increase in the same order. In conclusion, Japanese schoolchildren with E 4/3 already had an atherogenic serum lipid profile.