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A case of severe neonatal lupus erythematosus without cardiac or cutaneous involvement
Author(s) -
Selander B,
Cedergren S,
Domanski H
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb01398.x
Subject(s) - medicine , transplacental , systemic lupus erythematosus , lupus erythematosus , pregnancy , disease , connective tissue disease , heart block , fetus , autoantibody , dermatology , autoimmune disease , pediatrics , immunology , pathology , placenta , electrocardiography , antibody , genetics , biology
Neonatal lupus erythematosus is a disease primarily characterized by cardiac and/or cutaneous involvement. Liver and haematological involvement occur in a few cases and these are normally considered to be mild and transient complications. The disease is suspected to be caused by transplacental passage of maternal autoantibodies, primarily anti‐Ro/SSA and anti‐La/SSB, from mothers with systemic lupus erythematosus. Here we report a child with neonatal lupus erythematosus who died from severe liver and haematological disease when 2 d old. The baby had no cardiac or cutaneous involvement. The mother has had two subsequent pregnancies. In the first she had a boy without certain signs of neonatal lupus erythematosus. In the next pregnancy the child developed congenital complete heart block and cutaneous lesions.