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Neonatal flumazenil therapy reverses maternal diazepam
Author(s) -
Dixon JC,
Speidel BD,
Dixon JJ
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb00980.x
Subject(s) - flumazenil , medicine , diazepam , anesthesia , gestation , pregnancy , caesarean section , benzodiazepine , eclampsia , receptor , biology , genetics
A woman at 32 weeks' gestation with eclampsia was given 120 mg diazepam shortly before emergency caesarean section. The infant had persistent apnoea and required respiratory support. Spontaneous respiration began after intravenous flumazenil infusion was started. Diazepam and its active metabolites were assayed during and after 5 d of treatment with flumazenil.