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Bone age in 116 untreated patients with Turner's syndrome rated by a computer‐assisted method (CASAS)
Author(s) -
Schwarze CP,
Arens D,
Haber HP,
Wollmann HA,
Binder G,
Mayer EIE,
Ranke MB
Publication year - 1998
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1998.tb00922.x
Subject(s) - bone age , medicine , turner syndrome , bone maturation , bone mineral , turner's syndrome , pediatrics , osteoporosis
Bone age maturation in 116 untreated patients with Turner's syndrome was evaluated in a cross‐sectional and longitudinal analysis. A total of 265 radiographs were rated using the TW2‐RUS method on the computer‐assisted skeletal age score (CASAS) system. Bone age was found to be retarded from the chronological age of 3 to 6y. Between the ages of 7 and 12y bone age almost equalled chronological age and progressed normally at a rate of 1 y y −1 . Bone maturation slowed down thereafter and epiphyseal closure was not reached before the age of 17 y. Reference data are presented on bone age and a bone age maturation curve for untreated patients with Turner's syndrome to be used in clinical practice. In the assessment of bone age and bone age velocity in Turner's syndrome the CASAS system produced reliable and valid results. The absolute difference between repeated bone age ratings was 0.26“y”(median) with a range of 0.00‐0.56“y”. Future studies evaluating the effect of growth‐promoting treatment in Turner's syndrome should use a computerized method for the determination of bone age.