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Effect of 6 months of growth hormone treatment in young children with Prader—Willi syndrome
Author(s) -
Eiholzer U.,
Weber R.,
Stutz K.,
Steinert H.
Publication year - 1997
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb18374.x
Subject(s) - medicine , endocrinology , growth hormone treatment , growth hormone , body weight , hormone , fat mass , obesity , dual energy x ray absorptiometry , bone mineral , osteoporosis
Nine prepubertal children with Prader—Willi syndrome were treated with growth hormone (GH; 24 IU/m 2 /week) for 6 months. Mean height increased by 0.8 SD and mean weight for height decreased by 0.7 SD over this 6‐month treatment period. Body fat, measured by dual‐energy X‐ray absorptiometry, decreased by 22.5% over the period of GH treatment, whereas fat‐free mass increased by 14%. These preliminary results indicate that GH is effective in increasing height and normalizing body composition in patients with Prader—Willi syndrome. □ Body composition, growth hormone treatment, Prader—Willi syndrome, growth