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Hypogonadism and endocrine metabolic disorders in Prader—Willi syndrome
Author(s) -
Müller J.
Publication year - 1997
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb18371.x
Subject(s) - medicine , hypogonadotrophic hypogonadism , endocrinology , endocrine system , hypogonadotropic hypogonadism , hypothalamic disease , thyroid function , thyroid , metabolic syndrome , hormone , adrenal insufficiency , diabetes mellitus
Disturbances of the hypothalamic—pituitary—gonadal axis are reviewed in patients with Prader—Willi syndrome, and a brief account is given of thyroid function, adrenal function and glucose metabolism in such patients. Cryptorchidism, hypoplastic external genitalia and delayed or incomplete pubertal development in most patients with Prader—Willi syndrome suggest dysfunction of the hypothalamic—pituitary—gonadal axis. Decreased levels of gonadotrophins, consistent with hypogonadotrophic hypogonadism, have been found in some patients, whereas others appear to have hypergonadotrophic hypogonadism secondary to cryptorchidism and its treatment. Gonadal function is normal in a small number of patients with the syndrome. Although most clinicians agree that cryptorchidism should be corrected in early childhood, in practice the surgery is often not performed. In addition, most patients do not receive sex hormone replacement therapy. It is therefore suggested that more aggressive endocrine treatment strategies for hypogonadism are warranted in both children and adults with Prader—Willi syndrome. Both thyroid function and adrenal function appear to be normal in most patients, and glucose metabolism is similar to that in normal obese individuals.