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Long‐term effects of intrauterine growth retardation
Author(s) -
Kjellmer I.,
Liedholm M.,
Sultan B.,
Wennergren M.,
Götborg C. Wallin,
Thordstein M.
Publication year - 1997
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb18352.x
Subject(s) - growth retardation , medicine , litter , endocrinology , physiology , pediatrics , pregnancy , biology , genetics , agronomy
Intrauterine growth retardation (IUGR) was studied both after experimental induction in rats and spontaneously occurring in man. The growth‐retarded rat pups were compared to appropriately grown litter mates with developmental and behavioural tests at 50 and 90 days of age. Female rats exhibited no differences between growth‐retarded and control rats but growth‐retarded male rats had poor performance at 50 but not at 90 days compared to male controls. In the patient study 25 growth‐retarded babies were compared with 21 appropriately grown controls. The growth‐retarded babies had delayed latency periods of the visual evoked potentials at term and 6 weeks later, and at follow‐up (18 months) demonstrated significantly more developmental and behavioural problems than the control group.