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Screening for complement deficiency in bacterial meningitis
Author(s) -
Ernst T,
Späth PJ,
Aebi C,
Schaad UB,
Bianchetti MG
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb15190.x
Subject(s) - medicine , meningitis , bacterial meningitis , complement (music) , immunology , pediatrics , intensive care medicine , genetics , complementation , biology , gene , phenotype
Seventy‐seven children with bacterial meningitis were screened for complement deficiency. Both the classical and the alternate pathways were normal in 75 patients. Transiently reduced total haemolytic activity of the classical pathway was documented in a boy with meningococcal meningitis. Total haemolytic activity of both the classical and the alternate pathways were reduced in another patient with pneumococcal meningitis: individual complement components determination indicated predominant activation of the alternate pathway.