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First‐trimester invasive procedures and congenital abnormalities *
Author(s) -
Greenough A.,
Naik S.,
Yuksel B.,
Thompson PJ,
Nicolaides KH
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb14850.x
Subject(s) - medicine , pediatrics , obstetrics
A prospective study was undertaken to determine whether first‐trimester amniocentesis or chorion villus sampling was associated with an increased incidence of congenital anomalies. The infants of mothers who had undergone first‐trimester amniocentesis (EA) ( n = 352), chorion villus sampling (CVS) ( n = 348) or no invasive antenatal procedure (controls) ( n = 264) were examined at a median age of 5 months. Both the EA and CVS groups had a higher proportion of infants with congenital anomalies ( n = 18 and n = 22, respectively) than the control group ( n =4) ( p < 0. 01). Certain of the abnormalities, however, affected only single infants. Compression abnormalities were more common in the EA group than in the controls ( p < 0. 05), but not in the CVS group. The isolated limb abnormalities which occurred were minor anomalies affecting the digits and were seen in both the CVS ( n = 6) and EA ( n = 3) groups. First‐trimester invasive procedures are thus associated with an excess of congenital anomalies.