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Low density lipoprotein in neonates with high cord serum cholesterol levels
Author(s) -
SánchezMuniz FJ,
Bastida S,
Perea S,
Cuesta C,
Aragonés A
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb09033.x
Subject(s) - cord blood , cholesterol , medicine , triglyceride , endocrinology , apolipoprotein b , high density lipoprotein , ldl cholesterol , low density lipoprotein , cord , lipoprotein , total cholesterol , surgery
Differences in cord serum low density lipoprotein (LDL) composition between male and female neonates with normal or high (≥ 100 mg/dl or ≥ 2.59 mmol/1) serum cholesterol levels were studied in 548 full‐term newborn infants of the Toledo Study (Spain), where the absence of known perinatal factors that would alter lipid levels in cord blood was confirmed. The percentage of females with a high serum total cholesterol (TC) level was higher ( p < 0.02) than that of males. ANOVA two‐way analysis shows significant interaction of gender and cholesterol level upon LDL‐cholesterol, triglycerides and LDL cholesterol/Apoprotein (Apo) B ratio. However, Apo B was higher in those neonates, both male and female, with high cholesterol levels. The LDL fraction carried about 55% of TC in females with high TC levels (HF), whereas it transported just 40% in males with high TC levels (HM). LDL appeared more enriched in cholesterol than in Apo B in HF than in HM ( p < 0.01). An increased level of small LDL particles should be associated with the higher triglyceride level found amongst HM. Results in LDL composition suggest that metabolic gender‐related differences in infants with normal or high TC are presented at birth.