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Plasma and tissue levels of lipids, fatty acids and plasma carnitine in neonates receiving a new fat emulsion
Author(s) -
Magnusson G,
Boberg M,
Cederblad G,
Meurling S
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08948.x
Subject(s) - fat emulsion , parenteral nutrition , adipose tissue , carnitine , medicine , arachidonic acid , linoleic acid , emulsion , docosahexaenoic acid , endocrinology , linolenic acid , fatty acid , clearance , metabolism , biochemistry , chemistry , polyunsaturated fatty acid , enzyme , urology
This study was undertaken to compare Intralipid® with a new fat emulsion containing gamma‐linolenic acid and carnitine, named Pediatric Fat Emulsion 4501, in neonates with regard to lipid and carnitine metabolism over a short period of total parenteral nutrition. There were 10 neonates in each group and they tolerated the total parenteral nutrition well. In spite of the gamma‐linolenic acid supplementation in the new emulsion, arachidonic acid decreased significantly in plasma lipid esters and adipose tissue in both groups after 5 d of treatment. Also, there was a decrease in plasma docosahexaenoic acid which was more pronounced in the treatment group. The relative percentage values of linoleic and linolenic acids in adipose tissue were increased, indicating that newborns have a rapid accretion of fatty acids. Plasma triglycerides were effectively cleared during the periods without fat infusion. In the group that received Pediatric Fat Emulsion 4501 the means of both free and total plasma carnitine concentrations increased significantly, whereas they tended to decrease in the Intralipid® group.