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Primary infections of human herpesvirus‐7 and herpesvirus‐6: a comparative, longitudinal study up to 6 years of age
Author(s) -
Huang LM,
Lee CY,
Liu MY,
Lee PI
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08942.x
Subject(s) - human herpesvirus 6 , serology , medicine , titer , longitudinal study , antibody , virology , herpesviridae , immunology , indirect immunofluorescence , human herpesvirus , age groups , virus , viral disease , pathology , demography , sociology
In order to understand the infection status of human herpesvirus 7 (HHV‐7) in Taiwan and clarify the serological cross‐reactivity between HHV‐7 and HHV‐6, a longitudinal study was carried out in 52 infants from whom 9 sera were available from birth to 6 years of age. All sera were tested for antibodies against HHV‐6 and HHV‐7 by indirect immunofluorescence assay. HHV‐7 infection was not seen before 6 months of age and gradually emerged thereafter, reaching a cumulative rate of 28.8%, 67.3%, 73.1 %, 78.8%, 82.7%, and 86.5% by the ages of 1. 2, 3, 4, 5 and 6 years, respectively. Primary HHV‐6 infection induced a reactive HHV‐7 antibody in 10/28 (35.7%) cases with a titre of no more than 10. Twenty‐eight children (53.8%) were infected by HHV‐6 earlier than HHV‐7. while eight (15.4%) were infected by HHV‐7 earlier than HHV‐6. In summary, HHV‐7 infected children later than HHV‐6. A one‐way cross‐reaction of HHV‐7 serology by HHV‐6 was revealed and a titre of 20 is appropriate for defining HHV‐7 infection.