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Oral immunoglobulin treatment in Crohn's disease
Author(s) -
Tjellström B,
Stenhammar L,
Magnusson KE,
Sundqvist T
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08873.x
Subject(s) - medicine , crohn's disease , antibody , intestinal permeability , gastroenterology , disease , immunoglobulin g , urinary system , immunoglobulin a , immunology
Two patients with severe Crohn's disease who failed to respond to traditional medical treatment were given immunoglobulin orally. We used the 6‐h urinary recovery of a mixture of polyethyleneglycols PEG 400 and 1000 (molecular weight range 282–1250 Da) to test the intestinal permeability. Both patients showed a similar permeability pattern with an increased leakage of large‐sized PEGs before treatment and a lower urinary recovery of probes after treatment with immunoglobulin. This might indicate that the inflammatory process in Crohn's disease can be affected from the luminal side of the mucosa.