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Selective compartmentalization of γσ‐T lymphocytes in human breastmilk
Author(s) -
Lindstrand A,
Smedman L,
Gunnlaugsson G,
TroyeBlomberg M
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08617.x
Subject(s) - medicine , compartmentalization (fire protection) , immunology , biochemistry , enzyme , chemistry
In human breastmilk, T lymphocytes with γδ‐receptor (TCR) are more frequent than those with αβ‐TCR, in comparison with peripheral blood. Differential representation has also been demonstrated for subpopulations of γδ‐T cells. Reactivity was visualized with three monoclonal antibodies against Vδ1, Vδ2 and Vγ2 on T cells from the breastmilk and peripheral blood of 12 women who had recently given birth. Confirming the results with Vδ1, it was found that Vδ1 ( p < 0.01) and Vγ2 ( p < 0.05) but not Vδ2 were overrepresented on T cells in milk as compared with blood. This selective compartmentalization seems to reflect the homing of certain cells to the mammary gland.