Premium
Prognostic impact of bone marrow karyotype in childhood acute lymphoblastic leukaemia: Swedish experiences 1986‐91
Author(s) -
Forestier E,
Gustafsson G,
Heideman A,
Heim S,
Hernell O,
Mitelman F,
Nordenson I,
Swolin B,
Söderhäll S
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08604.x
Subject(s) - karyotype , medicine , bone marrow , oncology , abnormality , chemotherapy , cytogenetics , acute lymphocytic leukemia , lymphoblastic leukemia , pathology , gastroenterology , leukemia , chromosome , biology , genetics , psychiatry , gene
The prognostic value of cytogenetic classification in acute lymphoblastic leukaemia (ALL) was evaluated in Swedish children below 16 years of age ( n = 372) diagnosed between 1986 and 1991. A bone marrow karyotype was obtained in 281 cases, of which 149 (53%) showed clonal abnormalities. Event‐free survival (p‐EFS) was 0.64–0.69 in patients with diploid and pseudodiploid karyotype. Patients with massive hyperdiploidy (> 50 chromosomes) had the best outcome (p‐EFS = 0.76) and those with hypodiploidy (< 46 chromosomes) had the worst (p‐EFS = 0.33). White blood cell count and age were the strongest predictors of outcome. The karyotype reached borderline significance. The diagnostic karyotype was also a predictor of outcome after relapse, with hyperdiploid patients doing better than the others. The presence of a structural chromosomal abnormality did not constitute a negative prognostic factor when intensive chemotherapy was given.