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Platelet serotonin transporter in coeliac disease
Author(s) -
Chiaravalloti G,
Marazziti D,
Batistini A,
Favilli T,
Ughi C,
Ceccarelli M,
Cassano GB
Publication year - 1997
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1997.tb08570.x
Subject(s) - serotonergic , coeliac disease , medicine , serotonin transporter , platelet , serotonin , transporter , endocrinology , disease , biochemistry , gene , biology , receptor
We investigated a peripheral serotonergic marker, i.e. platelet tritiated imipramine ( 3 H‐IMI) binding sites, which are part of the 5‐HT transporter complex similar to that present in the brain, in 20 patients affected by coeliac disease (CD), as compared with 20 healthy controls. Platelet membranes and 3 H‐IMI binding were carried out according to a standardized protocol. The results showed that coeliac patients had significantly lower H‐IMI binding sites than controls. This finding would suggest the presence of a dysfunction at the level of the 5‐HT transporter that might underline the psychic disturbances frequently observed in coeliac patients.