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Impact of reoxygenation with oxygen and air on the extent of the brain damage after hypoxia‐ischaemia in neonatal rats
Author(s) -
Bågenholm R.,
Hagberg H.,
Kjellmer I.
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb18234.x
Subject(s) - hypoxia (environmental) , brain damage , ischemia , oxygen , room air distribution , anesthesia , medicine , chemistry , physics , organic chemistry , thermodynamics
Brain damage after hypoxia‐ischaemia develops partly during the state of reoxygenation. The generation of free oxygen radicals is considered to be one possible mechanism. In order to evaluate the role of hyperoxygenation, a comparison was made between reoxygenation with pure oxygen and with air after hypoxia‐ischaemia in a rat model of unilateral cerebral hemisphere damage. Brain damage was induced in 7‐day‐old rats. The animals were treated during reoxygenation with either 100% oxygen for 0.5 h or air. The extent of the brain damage was determined at 3 weeks of age by weighing the left and right hemispheres separately. No significant difference in weight deficit of the hemispheres was seen in the oxygen‐treated group (15.5%, median) compared to the air‐treated group (25.0%). Reoxygenation with pure oxygen after hypoxia‐ischaemia in neonatal rats does not cause increased brain damage compared with reoxygenation with room air.