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Serological screening (antigliadin and antiendomysium antibodies) for non‐overt coeliac disease in children of short stature
Author(s) -
Lecea A,
RibesKoninckx C,
Polanco I,
Calvete J Ferrer
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14252.x
Subject(s) - coeliac disease , medicine , short stature , antibody , serology , gliadin , immunology , disease , gluten , pathology
This study aimed to assess the value of IgA‐antigliadin and antiendomysium antibodies for coeliac disease screening in children with short stature. In 118 children with height less than the 3rd percentile for age preliminary work‐up included absorption, hormonal and genetic studies, sweat test. X‐ray for bone age, serum immunoglobulin levels and antigliadin antibodies. In 65 patients antiendomysium antibody and a small‐intestinal biopsy were performed. Forty‐three children had a normal mucosa and 22 a subtotal villous atrophy. Three coeliac children were negative for both antigliadin and antiendomysium antibodies; one further 11‐year‐old boy was negative only for antiendomysium antibodies. Sensitivity and specificity for antigliadin antibodies were 94.75% and 93%, respectively, and for antiendomysium antibodies 88.3% and 90.5%. Our results show that the use of antiendomysium antibodies as a confirmatory test to select patients for biopsy could result in coeliac disease going undiagnosed in adolescents.