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Allergy development and macromolecular absorption in infants with different feeding regimens during the first three days of life. A three‐year prospective follow‐up
Author(s) -
Juvonen P,
Månsson M,
Andersson C,
Jakobsson I
Publication year - 1996
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14215.x
Subject(s) - medicine , radioimmunoassay , allergy , breastfeeding , immunoglobulin e , casein , physiology , pediatrics , immunology , gastroenterology , antibody , food science , chemistry
A group of 129 infants were randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF) or a casein hydrolysate formula (CHF) during the first 3 days of life. Blood samples were taken on at 4 days and at 2, 4, 8, 12 and 24 months of age. Macromolecular absorption was analysed by measuring the serum concentration of human α‐lactalbumin (S‐α‐LA) with a competitive radioimmunoassay (RIA). Total serum IgE was measured by RIA. A family history of allergy correlated to the proportion of infants with allergic symptoms both at 24 and 36 months of age ( p = 0.03 and p = 0.04 respectively). In none of the three groups did correlation exist between the duration of breastfeeding and serum α‐LA, serum IgE, family history of allergy, frequency of allergic symptoms and proportion of infants with infections.