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Circulating noradrenaline and β‐adrenergic receptors in children with congestive heart failure
Author(s) -
Wu JR,
Chang HR,
Chen SS,
Huang TY
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14187.x
Subject(s) - heart failure , medicine , lymphocyte , adrenergic receptor , catecholamine , cardiology , adrenergic , endocrinology , receptor
This study was designed to investigate changes in plasma catecholamine concentrations and the number of β‐adrenoceptors (β‐AR) of circulating lymphocyte in 94 noncyanotic congenital heart patients, in 43 patients with congestive heart failure, β‐AR density was significantly lower ( p < 0.001) and plasma noradrenergic levels were significantly higher ( p < 0.001) compared with corresponding values in 51 patients without heart failure. A significant negative correlation between lymphocyte β‐AR density and plasma noradrenergic levels was observed ( r =−0.61, p < 0.001). The degree of left‐to‐right shunt and pulmonary pressure was correlated directly with noradrenaline level and inversely with lymphocyte β‐AR density. Both plasma noradrenaline level and lymphocyte β‐AR density return to normal in children with heart failure after surgical repair. Our results support the idea that changes in noradrenaline level and lymphocyte β‐adrenoceptor density occur concurrently with the presence and severity of heart failure in children.