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Cerebrospinal fluid concentrations of leukotriene B 4 in bacterial meningitis
Author(s) -
Santer R,
Sievers E,
Schaub J
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14181.x
Subject(s) - cerebrospinal fluid , medicine , aseptic meningitis , meningitis , granulocyte , bacterial meningitis , csf albumin , pathophysiology , leukotriene b4 , immunology , leukotriene , pathology , inflammation , asthma , surgery
We investigated whether leukotriene B 4 (LTB 4 ), a granulocyte inflammatory mediator, is detectable in cerebrospinal fluid using a high performance liquid chromatographic method. In non‐pleocytotic cerebrospinal fluid (n = 5) and in cerebrospinal fluid from children with aseptic meningitis (n = 8). LTB 4 concentrations were below the detection limit (<0.2ngml 1 ). In the range 0 20ngml 1 . the recovery rate of LTB 4 that had been added to non‐pleocytotic cerebrospinal fluid was >90%. In cerebrospinal fluid with a polymorphonuclear leucocyte (PMN) count higher than 1,000/ml, LTB 4 was detectable in six out of seven specimens with a concentration of 0.35‐3.3 ngml −1 . LTB 4 concentration was significantly correlated with PMN number. These results, together with observations in animal models, are discussed with regard to a pathophysiological role of LTB 4 in bacterial meningitis.