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Antiepileptic drug treatment during pregnancy and neonatal screening results
Author(s) -
Wide K,
Winbladh B,
Guthenberg C,
Döbeln U von
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14170.x
Subject(s) - medicine , drug , pregnancy , hormone , liver enzyme , drug metabolism , antiepileptic drug , physiology , thyroid hormones , endocrinology , pharmacology , epilepsy , genetics , psychiatry , biology
Many antiepileptic drugs induce hepatic metabolic enzymes and thus enhance metabolism of steroid and thyroid hormones. Antiepileptic drugs readily cross the placenta and the foetal liver is metabolically active. We therefore evaluated the neonatal screening results of TSH and 17‐hydroxyprogesterone in 34 study children and their matched controls. There were no statistically significant differences in the results between the groups.