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Serum and salivary antigliadin antibodies and serum IgA anti‐endomysium antibodies as a screening test for coeliac disease
Author(s) -
Rujner J,
Socha J,
Barra E,
Gregorek H,
Madaliński K,
Woźniewicz B,
Giera B
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14157.x
Subject(s) - endomysium , coeliac disease , antibody , gliadin , medicine , immunology , saliva , villous atrophy , immunoglobulin a , immunoglobulin g , disease , gluten , pathology
Serum and salivary IgA and IgG antigliadin antibodies were determined by an enzyme‐linked immunosorbent assay in 18 children with villous atrophy and 30 children on a gluten‐free diet for coeliac disease in whom normal intestinal mucosa was found. Serum IgA anti‐endomysium antibodies were also determined by an immunofluorescence method in these children. Serum IgG antigliadin and IgA anti‐endomysium antibodies had the highest sensitivity (100 and 94.4%, respectively), followed by serum IgA antibodies to gliadin (72.2%), salivary IgA antigliadin (61.2%) and IgG antigliadin (50%) antibodies. The highest specificity was found for serum IgA anti‐endomysium (100%) and IgA antigliadin (96.6%) antibodies and salivary IgA and IgG antigliadin antibodies (93.3%), while serum IgG antigliadin antibodies were found to be least specific (63.3%)