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Does the classification system fit disease progression in perinatal human immunodeficiency virus infection?
Author(s) -
Martino M de,
Zappa M,
Galli L,
Rossi ME,
Vierucci A
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14134.x
Subject(s) - medicine , pediatrics , human immunodeficiency virus (hiv) , disease , virus , immunology
The objective was to test the applicability of the new classification for paediatric human immonodeficiency virus infection. The person‐time of each state, transition probabilities and survival (± standard errors) at 5 years, and median sojourn‐time were calculated on 39 perinatally infected children followed up from the first month of life for a median of 64.5 (1.2‐120.1) months. The person‐times of the N2, N3, B1, C1, and C2 states were low. The transition probabilities and sojourn‐times were similar for A (48.1 ± 10.8%; 63.5 months), B (50.5 ± 15.5%; 44.9 months) and C (74.6 ± 15.1%; 43.1 months) clinical categories, which differed ( p < 0.025) from the N category (87.9 ± 5.5%; 12.05 months). The survival probabilities after 5 years of entering the A, B and C categories were 84.8 ± 10.7%, 60.5 ± 19.8% and 14.8 ± 13.5%, respectively ( p < 0.001). Immunological category 3 had lower transition probabilities and longer sojourn‐times (58.8 ± 16.6%; 53.3 months) than categories 1 (71.3 ± 8.1%; 33.2 months) and 2 (75.6 ± 10.5%; 19.8 months) ( p < 0.01). The transition probabilities to C3 for states N3, A3 or B3 were 52.5 ± 13.5%. In conclusion, the classification tits the clinical history better than the immunological history.