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Serum interleukin‐1β in neonatal sepsis
Author(s) -
Atici A,
Satar M,
Alparslan N
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14036.x
Subject(s) - medicine , sepsis , neonatal sepsis , immunology , interleukin , intensive care medicine , cytokine
Serum levels of interleukin‐1β (IL‐1β) in newborn infants with septicaemia were measured and possible relationships between the clinical course of the infants, causative micro‐organisms and IL‐1β levels were investigated in a prospective study. The study groups comprised 49 newborn infants (25 mature, 24 premature) with proven sepsis and 40 healthy newborn infants (20 mature, 20 premature). Serum IL‐1β levels were measured using the IL‐1β immunoradiometric assay. The levels were found to be lower in neonates with sepsis (median 0.1 pg/ml) than in healthy controls (median 27.9 pg/ml) ( p <0.001). Non‐significant trends towards lower levels were observed in children with shock and in non‐survivors. No correlation was found between IL‐1β and postnatal age, gestational age or the study weight of the patients. There was no significant difference in the serum IL‐1β level in septic patients infected with Gram‐positive bacteria and those infected with Gram‐negative bacteria. The results show that the concentration of IL‐1β is significantly decreased in preterm and term neonates with sepsis.