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Long‐term pulmonary function in children with Hodgkin's disease
Author(s) -
Ilhan I,
Sarialioǧlu F,
Bilgiç H,
Göçmen A,
Büyükpamukcu M,
Akyüz C,
Kutluk T
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14025.x
Subject(s) - medicine , term (time) , pulmonary function testing , disease , intensive care medicine , pediatrics , lung function , lung , physics , quantum mechanics
We studied the long‐term pulmonary function of 25 patients who were at least 5 years post‐treatment for Hodgkin's disease. The mean age of the patients was 17 years (range 9.5–25 years) at the time of study. Twenty‐one of the patients were male. All patients received six courses of COPP chemotherapy and, in addition, 8 of the 25 patients received radiotherapy to the mediastinum in low or moderate doses (20–30 Gy). One patient had symptoms of bronchiectasia. The chest radiographs of nine patients (36%) showed minimal abnormalities. We divided patients into two groups while evaluating their pulmonary function tests according to whether they received mantle irradiation or not. In patients who received mantle irradiation, pulmonary function tests showed a minimal decrease in FEV 1 . The decrease in FEV 1 indicated an obstructive ventilatory defect. We concluded that our treatment protocols for paediatric Hodgkin's disease were curative, well tolerable and might minimize pulmonary functional changes.