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Outcome of idiopathic membranoproliferative glomerulonephritis in children
Author(s) -
Schwertz R,
Jong R,
Gretz N,
Kirschfink M,
Anders D,
Schärer K
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14022.x
Subject(s) - membranoproliferative glomerulonephritis , medicine , nephrotic syndrome , gastroenterology , nephritic syndrome , glomerulonephritis , kidney
The aim of this multicentre study was to analyse the long‐term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2 14 years at the onset of the study were followed over 2 20 years; 26 patients had MPGN type I, 17 had type II and 7 had type III. Treatment was variable. At the last observation, 30 patients had reached terminal and four pre‐terminal renal failure. The median survival probability until renal death was 15.3, 8.7 and 15.9 years for disease types I, II and III respectively (difference between MPGN types I + III versus type II: p = 0.013). The presence of an initial nephrotic syndrome was associated with a more rapid progression ( p = 0.018). C3 nephritic factor was of no prognostic value. We conclude that the outcome of MPGN mainly depends on the histological type observed.