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Relationship of interleukin‐8 and colony‐stimulating factors to neutrophil migration in aseptic meningitis
Author(s) -
Yokoyama T,
Oda M,
Ogura S,
Horiuchi T,
Seino Y
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14021.x
Subject(s) - cerebrospinal fluid , aseptic meningitis , medicine , granulocyte colony stimulating factor , meningitis , csf albumin , granulocyte , immunology , granulocyte macrophage colony stimulating factor , macrophage colony stimulating factor , cytokine , macrophage , biology , biochemistry , chemotherapy , psychiatry , in vitro
Polymorphonuclear neutrophilic leucocyte (PMNL) migration into the subarachnoid space in aseptic meningitis of probable enteroviral aetiology was evaluated in relation to cerebrospinal fluid and serum levels of interleukin‐8 (IL‐8), macrophage colony‐stimulating factor (M‐CSF) and granulocyte colony‐stimulating factor (G‐CSF). IL‐8 levels reached a plateau within 12 h of onset, while M‐CSF and G‐CSF levels reached a peak between 12 and 24 h after onset, corresponding to the peak increase in PMNL count. G‐CSF levels had the closest correlation with PMNL count. M‐CSF levels were weakly correlated with PMNL count. IL‐8 levels were not correlated with PMNL count except within 12 h of onset. IL‐8 and G‐CSF were detected predominantly in cerebrospinal fluid, while the M‐CSF levels in the two compartments were not different except between 12 and 24 h after onset. It is considered that IL‐8 triggers rapid and transient migration of PMNL, and that G‐CSF then promotes gradual and consistent infiltration of PMNL.