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Focal intestinal perforation in preterm infants is an emerging disease
Author(s) -
Raghuveer G,
Speidel B,
Marlow N,
Porter H
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb14000.x
Subject(s) - medicine , ductus arteriosus , gestation , pathogenesis , perforation , intraventricular hemorrhage , fetus , hypoxia (environmental) , catheter , pregnancy , bowel perforation , obstetrics , gestational age , gastroenterology , surgery , complication , chemistry , genetics , materials science , organic chemistry , oxygen , metallurgy , punching , biology
In order to elicit the pathogenesis of focal intestinal perforation in preterm infants we contrasted 8 infants who developed this disease with 16 gestation‐matched controls. The cases were found to have lower birthweights for gestation (median standard deviation score of −1.02 in cases versus −0.08 in controls), and more frequently had preexisting patent ductus arteriosus and intraventricular haemorrhage (88 and 63% in cases versus 25 and 6% in controls, respectively). There were similar rates of other perinatal variables in the two groups, including indomethacin and umbilical arterial catheter use. Conditions associated with fetal or neonatal hypoxia are important antecedents for this emerging distinct clinical entity.