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Transient hypertriglyceridemia of infancy
Author(s) -
Nilsson A,
Örtqvist E,
Lagercrantz H,
Nilsson–Ehle P,
Henter JI
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb13964.x
Subject(s) - hypertriglyceridemia , medicine , lipoprotein lipase , hyperlipidemia , endocrinology , hepatic lipase , lipoprotein , bronchopulmonary dysplasia , triglyceride , cholesterol , gestational age , biology , pregnancy , genetics , adipose tissue , diabetes mellitus
A premature boy who had suffered from IRDS, bronchopulmonary dysplasia and retinopathy of prematurity developed massive hypertriglyceridemia (48.1 mmol/L) together with moderate hypercholesterolemia (12.6 mmol/L) at 5 months of age. Lipoprotein electrophoresis revealed a marked elevation of the level of the very low density lipoprotein fraction. There was a moderate decrease in the activity of a lipolytic enzyme, lipoprotein lipase (LPL). The child had neither liver or renal disorder nor any inflammatory disease. The hyperlipidemia disappeared spontaneously at the age of 3 years. The cause of the decreased LPL activity could not be established. A partial genetic deficiency in lipoprotein lipase appears the most likely explanation, since no signs of secondary lowering of LPL activity could be found.