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Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies
Author(s) -
Bonamico M,
RasoreQuartino A,
Mariani P,
Scartezzini P,
Cerruti P,
Tozzi MC,
Cingolani M,
Gemme G
Publication year - 1996
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1996.tb13962.x
Subject(s) - medicine , coeliac disease , antibody , gastroenterology , gliadin , biopsy , disease , immunology , pathology , gluten
The usefulness of antigliadin (AGA) and antiendomysium antibodies (EMA) as a screening test for coeliac disease (CD) in 113 Down syndrome (DS) patients (61 children) was evaluated. AGA IgA were present in 22.1%, AGA IgG in 48.6%, EMA in 6.2%. Four symptomatic patients, AGA‐ and EMA‐positive, were affected by CD (3.5%). In three AGA‐ and EMA‐positive subjects, permission for intestinal biopsy was refused, while in two AGA‐positive and EMA‐negative children, the intestinal mucosa was normal. Our study confirms the association of CD and DS, and suggests the usefulness of EMA determination as a test for selecting DS patients for intestinal biopsy.