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Low levels of plasminogen in cerebrospinal fluid after intraventricular haemorrhage: a limiting factor for clot lysis?
Author(s) -
Whitelaw A,
Mowinckel MC,
Abildgaard U
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13795.x
Subject(s) - medicine , fibrinolysis , cerebrospinal fluid , hydrocephalus , intraventricular hemorrhage , thrombolysis , urokinase , anesthesia , surgery , pregnancy , gestational age , biology , myocardial infarction , genetics
The aim of this study was to measure plasminogen in the cerebrospinal fluid (CSF) of control neonates with no infection or haemorrhage and in infants who had suffered intraventricular haemorrhage (IVH). A chromogenic substrate method was used. The 16 reference infants had a median CSF plasminogen level of 0.74% of that of normal adult plasma (range 0.17‐1.1%). The 11 infants with IVH had a median CSF plasminogen level of 0.55% of normal adult plasma (range 0‐4.4%). Six of the IVH infants went on to develop permanent hydrocephalus despite the use of intraventricular plasminogen activators. Endogenous fibrinolysis and the potential for fibrinolytic treatment in the CSF may be limited by low concentrations of plasminogen, and administration of recombinant plasminogen may assist attempts to clear intraventricular blood clots. Cerebrospinal fluid, hydrocephalus, intraventricular haemorrhage, newborn infant, plasminogenA Whitelaw, Department of Paediatrics, Aker University Hospital, 0514 Oslo, Norway