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Plasma growth hormone response to growth hormone‐releasing hexapeptide (GH‐RP‐6) in children with short stature
Author(s) -
Pombo M,
Barreiro J,
Penalva A,
Mallo F,
Casanueva FF,
Dieguez C
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13790.x
Subject(s) - medicine , short stature , idiopathic short stature , endocrinology , growth hormone , stimulation , growth hormone deficiency , hormone
Eighteen children with short stature were evaluated for growth hormone (GH) reserve after pharmacological tests and a single iv injection of GH‐RP‐6. These children were divided into two groups: 10 were diagnosed as having idiopathic GH deficiency by classical stimulation tests (group A) and the remaining 8 (group B) were considered growth‐retarded children with normal GH secretion, following conventional stimulation, but reduced endogenous GH secretion. The results were compared with a group of 12 normal children. As a group, patients in group A showed a lower GH response to GH‐RP‐6, while patients in group B had a similar response as normal controls. However, on an individual basis, a considerable degree of overlapping in responses among the three groups was evident. These data indicate that, on an individual basis, GH‐RP‐6 testing is not of diagnostic value in children suspected of having idiopathic GH deficiency. GH deficiency, GH‐RP‐6, short statureC Dieguez, PO Box 563, 15705 Santiago de Compostela, Spain