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Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections
Author(s) -
Scedmyr J,
Nyberg E,
ÅsbrinkNilsson E
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13786.x
Subject(s) - budesonide , medicine , placebo , asthma , evening , upper respiratory tract infection , exacerbation , morning , respiratory tract infections , respiratory tract , anesthesia , asthma exacerbations , respiratory system , pediatrics , physics , alternative medicine , pathology , astronomy
Upper respiratory tract infection (URTI) is a common cause of deterioration of asthma in children. We investigated if inhaled steroids (budesonide), started early after URTI, could reduce asthma. Thirty‐one children, 3‐10 years of age, with deterioration during URTI participated. The study design was double‐blind, crossover and placebo‐controlled. Peak‐expiratory flow (PEF) and symptom scores were recorded. Four treatment periods of 9 days, two with budesonide and two with placebo, were planned. Treatment was started at the first sign of URTI. Budesonide/placebo was given by Turbuhaler at 0.2 mg qid for 3 days, tid for 3 and bid for the last 3 days. Twenty‐two children completed 67 periods. Eleven visited the emergency room, only three during budesonide therapy. Five received oral steroids and two where admitted to hospital, all receiving placebo. Symptom scores were not significantly lower during budesonide treatment. PEF, both morning and evening, was significantly higher during budesonide than placebo (p = 0.015 and p = 0.022). Inhaled budesonide can attenuate exacerbation of URTI‐induced asthma. Asthma, budesonide, infection, inhaled steroids, intermittent, prophylacticJ Svedmyr, Department of Paediatrics, Falu Hospital, S‐791 82 Falun, Sweden