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Allogeneic bone marrow transplantation in children: single institution experience from 1974 to 1992
Author(s) -
Mäkipernaa A,
Saarinen UM,
Siimes MA
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13729.x
Subject(s) - medicine , bone marrow transplantation , aplastic anemia , bone marrow , pediatrics , surgery , transplantation , leukemia , bone marrow failure , anemia , haematopoiesis , stem cell , biology , genetics
At the Children's Hospital, University of Helsinki, Finland, bone marrow transplantations have been performed since 1974. Between 1974 and 1992, 62 children received allogeneic bone marrow grafts. Median patient age was 9.3 years. Thirty‐two patients had ALL, 13 AML and 11 had severe aplastic anemia (SAA). Graft failure occurred in 4 of the 62 patients. The overall long‐term survival rate was 47%. Relapse of leukemia was the most common cause of death, especially in patients with ALL transplanted in second or later remission. Deaths during the first 2 months after transplant have decreased with time. In a small country such as Finland, it is important to centralize the experience of allogeneic BMTs, particularly for pediatric patients.