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Adverse drug reactions in a paediatric intensive care unit
Author(s) -
Gill AM,
Leach HJ,
Hughes J,
Barker C,
Nunn AJ,
Choonara I
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13667.x
Subject(s) - medicine , paediatric intensive care unit , drug reaction , intensive care medicine , intensive care unit , drug , medline , pediatrics , medical emergency , pharmacology , political science , law
Adverse drug reactions (ADRs) were prospectively studied in critically ill infants and children. Seventy–six ADRs were reported in 63 patients out of a study group of 899 patients. The majority of the ADRs were mild (49), although 19 were of moderate severity and 8 were severe. Thirty–five ADRs required treatment or alteration in treatment. Midazolam, morphine, salbutamol, vecuronium, hydrocortisone and theophylline were the drugs most likely to cause an ADR. One–third of the ADRs were due to drugs used outside their product licence. The majority of the ADRs were reported by nurses (36) and pharmacists (30). We believe that it is possible to prospectively study drug toxicity in critically ill infants and children.