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Peripheral blood γδ T cells in human listeriosis
Author(s) -
Bertotto A,
Spinozzi F,
Gerli R,
Bassotti G,
Forenza N,
Vagliasindi C,
Vaccaro R
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13584.x
Subject(s) - listeria monocytogenes , monoclonal antibody , immune system , medicine , immunology , immunofluorescence , peripheral blood , intracellular , listeria , phenotype , receptor , antibody , monoclonal , gene , biology , microbiology and biotechnology , bacteria , genetics
A phenotypical analysis carried out by direct immunofluorescence and two‐colour cytofluorometry showed that the number of lymphocytes bearing the γδ T‐cell receptor heterodimer was increased in the blood of eight children with Listeria monocytogenes infection, mainly due to an expansion of cells identified by monoclonal antibodies which recognize Vγ2 gene products. These findings are further evidence that γδ T cells are in some way involved in the immune response directed against human intracellular pathogens.