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Intranasal versus intravenous administration of midazolam to children undergoing small bowel biopsy
Author(s) -
Högberg L,
Nordvall M,
Tjellström B,
Stenhammar L
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13582.x
Subject(s) - medicine , midazolam , sedation , anesthesia , nasal administration , group b , group a , nose , surgery , biopsy , randomized controlled trial , pharmacology
Sixty‐three children under the age of 9 years were randomized to receive intravenous (group A, n = 33) or intranasal (group B, n = 30) midazolam as sedation for small bowel biopsy. Mean doses of midazolam given to produce adequate sedation were 0.31 mg (kg body weight) −1 in group A and 0.34 mg (kg body weight) −1 in group B (NS). Four children in group A and 10 children in group B required additional doses to maintain adequate sedation throughout the biopsy procedure (p <0.05). There was no significant difference between the groups regarding the median procedure time (7 min in group A, 8.5 min in group B) or median fluoroscopy time (5 s in group A, 4 s in group B). All children in group B showed signs of discomfort from the nose when given midazolam intranasally. In conclusion, this study indicates that intravenous administration of midazolam is preferable to the intranasal route.