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Reduced carnitine and antiepileptic drugs: cause relationship or co‐existence?
Author(s) -
Zelnik N,
Fridkis I,
Gruener N
Publication year - 1995
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1995.tb13494.x
Subject(s) - valproic acid , carbamazepine , medicine , phenobarbital , carnitine , anticonvulsant , pharmacology , epilepsy , gastroenterology , anesthesia , psychiatry
Serum carnitine was measured longitudinally before and after therapy in 15 patients receiving valproic acid, 14 patients receiving carbamazepine and 8 patients receiving phenobarbital. The patients who received valproic acid showed a significant reduction in free (and total) serum carnitine (mean (SE) 37.6 (6.2)/umol/l without valproic acid, 29.1 (1.6)/xmol/l with valproic acid (p < 0.001)). Such an effect was not found in patients receiving carbamazepine or phenobarbital.