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Insulin‐like growth factor I actions on steroidogenesis
Author(s) -
Chatelain PG,
Avallet MO,
Nicolino M,
Lejeune H,
Clark A,
Chuzel F,
Penhoat A,
Saez JM
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13319.x
Subject(s) - endocrinology , medicine , endocrine system , insulin like growth factor , growth hormone , delayed puberty , growth factor , hormone , insulin resistance , receptor , insulin
The best evidence that insulin‐like growth factor I (IGF‐I) contributes to normal steroidogenesis comes from patients with growth hormone (GH) insensitivity syndrome due to deletion of the GH receptor gene. These patients have severe GH resistance and severe IGF‐I insufficiency, and present with markedly delayed puberty without gonadotrophin insufficiency. The same applies to patients with severe isolated GH insufficiency due to GH gene deletion, in whom GH treatment results in normalization of puberty and gonadal steroidogenesis. Delayed sexual maturation is also observed in GH‐deficient Snell dwarf mice. These observations strongly suggest that IGF‐I plays a role in the endocrine function and differentiation of the gonads.