Premium
Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins
Author(s) -
Fast Ch,
Rosegger H
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13253.x
Subject(s) - medicine , necrotizing enterocolitis , gentamicin , antibiotic prophylaxis , antibiotics , enterocolitis , group b , antibody , randomized controlled trial , gastroenterology , prospective cohort study , surgery , immunology , microbiology and biotechnology , biology
We conducted a prospective randomized trial to compare the efficacy of oral gentamicin versus oral IgA‐IgG for the prophylaxis of necrotizing enterocolitis (NEC); 200 newborns considered at high risk for NEC were assigned to group A (oral IgA‐IgG, n = 100) or group B (oral Gentamicin, n = 100). NEC was diagnosed in 13 cases in group A and in 1 case in group B between the 3rd and 16th days of life. Surgical treatment was necessary in 3 cases (2 in group A). All infants survived. We conclude that oral gentamicin is more effective than oral IgA‐IgG in the prevention of NEC in infants at high risk.