Premium
Platelet‐activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis
Author(s) -
Hsueh W,
Caplan MS,
Sun X,
Tan X,
MacKendrick W,
GonzalezCrussi F
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13234.x
Subject(s) - necrotizing enterocolitis , medicine , pathogenesis , hypoxia (environmental) , tumor necrosis factor alpha , platelet activating factor , enterocolitis , tumor necrosis factor α , immunology , pathology , oxygen , chemistry , organic chemistry
The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood. We have established several animal models of NEC by using a combination of various stimuli and stress, including endotoxin, PAF, TNF, and hypoxia. We discuss the mechanism of their actions and the possible roles of these factors in the pathogenesis of human NEC.