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Immunopathogenesis of chronic inflammatory bowel disease
Author(s) -
Braegger Christian P
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13223.x
Subject(s) - medicine , proinflammatory cytokine , immunology , pathogenesis , immune system , inflammatory bowel disease , circumstantial evidence , disease , etiology , complement system , immunity , inflammation , pathology , political science , law
The aetiology and pathogenesis of chronic inflammatory bowel disease are unknown. However, there is circumstantial evidence that immune mechanisms may play a significant role in mediating the gut lesion and various systemic manifestations. The role of the cellular immune system, soluble mediators, including proinflammatory and immunoregulatory cytokines, humoral immunity and mucosal complement activation will be discussed.